/* Layout: one left-aligned reading column with wide data bands; the allele strip (codons 112/158) is the signature element. */
:root{
  --bg:#f6f7f9; --surface:#ffffff; --ink:#14181f; --muted:#4a5260; --rule:#d9dde4;
  --e2:#2f7d6d; --e3:#5b6b86; --e4:#b0234f; --e4-soft:#f6e3ea;
  --display:'Spectral', Georgia, 'Times New Roman', serif;
  --body:'Public Sans', 'Helvetica Neue', Arial, sans-serif;
  --mono:'JetBrains Mono', ui-monospace, Menlo, Consolas, monospace;
}
@media (prefers-color-scheme: dark){:root:not([data-theme="light"]){
  --bg:#0f1217; --surface:#171b22; --ink:#e8ebf0; --muted:#a3abb8; --rule:#2a303a;
  --e2:#5cc0a8; --e3:#93a3bf; --e4:#ec6b93; --e4-soft:#3a1a26; color-scheme:dark}}
:root[data-theme="dark"]{
  --bg:#0f1217; --surface:#171b22; --ink:#e8ebf0; --muted:#a3abb8; --rule:#2a303a;
  --e2:#5cc0a8; --e3:#93a3bf; --e4:#ec6b93; --e4-soft:#3a1a26; color-scheme:dark}

*{box-sizing:border-box}
body{background:var(--bg);color:var(--ink);font-family:var(--body);font-size:17px;line-height:1.6;
  padding-left:max(16px, env(safe-area-inset-left, 0px));padding-right:max(16px, env(safe-area-inset-right, 0px))}
.wrap{max-width:1080px;margin:0 auto}
a{color:var(--e4);text-underline-offset:3px}
a:focus-visible,button:focus-visible{outline:2px solid var(--e4);outline-offset:3px}
h1,h2,h3{font-family:var(--display);font-weight:600;line-height:1.15;text-wrap:balance;margin:0}
p{margin:0}
.label{font-family:var(--mono);font-size:12.5px;letter-spacing:.08em;text-transform:uppercase;color:var(--muted)}
.prose{max-width:65ch;display:grid;gap:14px}

header.top{display:flex;justify-content:space-between;align-items:center;gap:16px;flex-wrap:wrap;padding-block:22px;border-bottom:1px solid var(--rule)}
.mark{font-family:var(--mono);font-weight:600;font-size:15px;letter-spacing:.02em;color:var(--ink);text-decoration:none}
.mark span{color:var(--e4)}
nav{display:flex;gap:22px;flex-wrap:wrap}
nav a{color:var(--muted);text-decoration:none;font-size:15px}
nav a:hover{color:var(--ink)}

.hero{display:grid;grid-template-columns:minmax(0,1.25fr) minmax(0,1fr);gap:56px;align-items:end;padding-block:72px 56px}
.hero h1{font-size:clamp(40px,6vw,68px);letter-spacing:-.01em}
.hero h1 em{font-style:italic;color:var(--e4);font-weight:400}
.hero .lede{font-size:19px;color:var(--muted);max-width:52ch;margin-top:22px}
.geno{font-family:var(--display);font-size:clamp(84px,13vw,150px);line-height:.9;color:var(--e4);letter-spacing:-.02em}
.geno small{display:block;font-family:var(--mono);font-size:13px;letter-spacing:.06em;color:var(--muted);margin-top:16px;text-transform:uppercase}

section{padding-block:64px;border-top:1px solid var(--rule)}
.sec-head{display:grid;gap:10px;margin-bottom:32px}
.sec-head h2{font-size:clamp(28px,3.4vw,38px)}

/* Allele strip */
.alleles{overflow-x:auto;background:var(--surface);border:1px solid var(--rule)}
table.allele{border-collapse:collapse;width:100%;min-width:560px;font-variant-numeric:tabular-nums}
table.allele th,table.allele td{padding:16px 18px;text-align:left;border-bottom:1px solid var(--rule)}
table.allele tr:last-child td{border-bottom:0}
table.allele th{font-family:var(--mono);font-size:12.5px;letter-spacing:.08em;text-transform:uppercase;color:var(--muted);font-weight:400}
.al{font-family:var(--display);font-size:24px;font-weight:600}
.res{display:inline-flex;align-items:center;gap:10px;font-family:var(--mono);font-size:15px}
.res b{display:inline-grid;place-items:center;width:34px;height:34px;border:1.5px solid currentColor;font-weight:600}
.c-e2{color:var(--e2)} .c-e3{color:var(--e3)} .c-e4{color:var(--e4)}
tr.is-e4 td{background:var(--e4-soft)}
.note{font-size:14.5px;color:var(--muted);margin-top:14px;max-width:70ch}

/* Findings */
.findings{display:grid;grid-template-columns:repeat(2,minmax(0,1fr));gap:0;border-top:1px solid var(--rule)}
.finding{padding:28px 28px 28px 0;border-bottom:1px solid var(--rule);display:grid;gap:10px;align-content:start}
.finding:nth-child(even){padding-left:28px;padding-right:0;border-left:1px solid var(--rule)}
.finding .fig{font-family:var(--display);font-size:44px;line-height:1;color:var(--e4)}
.finding p{color:var(--ink)}
.finding h3{font-size:22px}
.finding .src{font-size:13.5px;color:var(--muted)}

/* Questions */
ol.questions{list-style:none;padding:0;margin:0;display:grid;gap:0;counter-reset:q}
ol.questions li{counter-increment:q;display:grid;grid-template-columns:56px minmax(0,1fr);gap:16px;padding-block:20px;border-bottom:1px solid var(--rule)}
ol.questions li::before{content:"Q" counter(q);font-family:var(--mono);font-size:14px;color:var(--e4);padding-top:4px}
ol.questions h3{font-size:22px;margin-bottom:6px}
ol.questions p{color:var(--muted);max-width:65ch}

/* Study */
.study{display:grid;grid-template-columns:minmax(0,1.2fr) minmax(0,1fr);gap:48px}
dl.facts{margin:0;display:grid;gap:0;background:var(--surface);border:1px solid var(--rule);align-self:start}
dl.facts div{display:grid;grid-template-columns:130px minmax(0,1fr);gap:16px;padding:14px 18px;border-bottom:1px solid var(--rule)}
dl.facts div:last-child{border-bottom:0}
dl.facts dt{font-family:var(--mono);font-size:12.5px;letter-spacing:.06em;text-transform:uppercase;color:var(--muted);padding-top:3px}
dl.facts dd{margin:0}
ul.measures{margin:0;padding-left:20px;display:grid;gap:6px}

/* Contact */
.contact{display:flex;flex-wrap:wrap;gap:12px;align-items:center;margin-top:8px}
.email{font-family:var(--mono);font-size:16px;padding:10px 14px;background:var(--surface);border:1px solid var(--rule);user-select:all}
button.copy{font-family:var(--body);font-size:15px;font-weight:600;padding:10px 16px;background:var(--ink);color:var(--bg);border:0;cursor:pointer}
button.copy:hover{background:var(--e4)}
.disclaimer{margin-top:26px;padding:16px 18px;border-left:3px solid var(--e4);background:var(--surface);font-size:15px;color:var(--muted);max-width:70ch}

ul.refs{list-style:none;padding:0;margin:0;display:grid;gap:14px;max-width:80ch;font-size:15.5px}
ul.refs li{padding-bottom:14px;border-bottom:1px solid var(--rule)}
ul.refs .j{font-style:italic}

footer{padding-block:36px 48px;border-top:1px solid var(--rule);display:flex;justify-content:space-between;flex-wrap:wrap;gap:12px;color:var(--muted);font-size:14px}

@media (max-width:820px){
  .hero,.study{grid-template-columns:minmax(0,1fr);gap:32px}
  .hero{padding-block:48px 40px}
  .findings{grid-template-columns:minmax(0,1fr)}
  .finding,.finding:nth-child(even){padding:24px 0;border-left:0}
  dl.facts div{grid-template-columns:minmax(0,1fr);gap:2px}
}
@media (prefers-reduced-motion:no-preference){
  .geno{animation:rise .8s ease-out both}
  @keyframes rise{from{transform:translateY(8px)}to{transform:none}}
}

nav a[aria-current="page"]{color:var(--ink);font-weight:600;text-decoration:underline;text-decoration-color:var(--e4);text-decoration-thickness:2px;text-underline-offset:6px}
.page-head{padding-block:56px 8px;display:grid;gap:12px}
.page-head h1{font-size:clamp(34px,5vw,52px)}
.page-head .lede{font-size:18px;color:var(--muted);max-width:62ch}
.cards{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:0;border-top:1px solid var(--rule);border-left:1px solid var(--rule)}
.card{display:grid;gap:8px;align-content:start;padding:24px;border-right:1px solid var(--rule);border-bottom:1px solid var(--rule);text-decoration:none;color:var(--ink);background:var(--surface)}
.card:hover h3{color:var(--e4)}
.card h3{font-size:22px}
.card p{color:var(--muted);font-size:15.5px}
.group{display:grid;gap:14px;margin-bottom:40px}
.group h2{font-size:26px}
ul.refs li p.why{color:var(--muted);font-size:14.5px;margin-top:4px}
table.data{border-collapse:collapse;width:100%;min-width:760px}
table.data th,table.data td{padding:14px 16px;text-align:left;vertical-align:top;border-bottom:1px solid var(--rule);font-size:15px}
table.data th{font-family:var(--mono);font-size:12px;letter-spacing:.08em;text-transform:uppercase;color:var(--muted);font-weight:400}
table.data td:first-child{font-weight:600;white-space:nowrap}
.pill{display:inline-block;font-family:var(--mono);font-size:11.5px;letter-spacing:.04em;padding:2px 8px;border:1px solid currentColor;white-space:nowrap}
.pill.ok{color:var(--e2)} .pill.stop{color:var(--e4)} .pill.run{color:var(--e3)}
.signup{display:grid;grid-template-columns:minmax(0,1fr) minmax(0,480px);gap:40px;align-items:center}
.signup iframe{width:100%;max-width:480px;height:320px;border:1px solid var(--rule);background:#fff}
@media (max-width:820px){.signup{grid-template-columns:minmax(0,1fr)}}
td.asof{font-family:var(--mono);font-size:13px;color:var(--muted);white-space:nowrap}
.resources{display:grid;gap:0}
.resource{display:grid;grid-template-columns:minmax(0,240px) minmax(0,1fr);gap:32px;padding-block:32px;border-bottom:1px solid var(--rule);scroll-margin-top:24px}
.resource:first-child{padding-top:0}
.resource-head{display:grid;gap:8px;align-content:start}
.resource-head h2{font-size:28px}
.resource-head h2 a{color:var(--ink);text-decoration-color:var(--e4)}
.resource dl.facts div{grid-template-columns:110px minmax(0,1fr)}
@media (max-width:820px){.resource{grid-template-columns:minmax(0,1fr);gap:14px}.resource dl.facts div{grid-template-columns:minmax(0,1fr)}}
.skip{position:absolute;left:-9999px;top:0;background:var(--ink);color:var(--bg);padding:8px 14px;z-index:20}
.skip:focus{left:max(16px, env(safe-area-inset-left, 0px));top:8px}
dl.glossary div{grid-template-columns:260px minmax(0,1fr)}
dl.glossary dt{font-family:var(--body);text-transform:none;letter-spacing:0;font-size:14.5px;color:var(--ink);font-weight:600}
@media (max-width:820px){dl.glossary div{grid-template-columns:minmax(0,1fr)}}
@media (max-width:640px){
  header.top{flex-direction:column;align-items:flex-start;gap:12px;padding-block:16px}
  header.top nav{flex-wrap:nowrap;overflow-x:auto;max-width:100%;gap:18px;padding-bottom:6px;-webkit-overflow-scrolling:touch;scrollbar-width:thin}
  header.top nav a{white-space:nowrap}
}
@media (max-width:640px){
  table.data{min-width:0}
  table.data thead{position:absolute;left:-9999px}
  table.data tr{display:block;padding:14px 16px;border-bottom:1px solid var(--rule)}
  table.data td{display:grid;grid-template-columns:96px minmax(0,1fr);gap:10px;padding:5px 0;border:0;white-space:normal}
  table.data td::before{content:attr(data-label);font-family:var(--mono);font-size:11px;letter-spacing:.06em;text-transform:uppercase;color:var(--muted);padding-top:3px}
}
.updated{font-size:13.5px;color:var(--muted)}
@media (max-width:1000px){.cards{grid-template-columns:repeat(2,minmax(0,1fr))}}
@media (max-width:560px){.cards{grid-template-columns:minmax(0,1fr)}}