A community resource
Two copies of APOE4 may be a genetic form of Alzheimer’s disease.
Evidence, data resources, papers, trials and drugs on APOE ε4 homozygosity, gathered in one place for the community.
Just learned you are ε4/ε4? Start here.
ε4/ε4About 2–3% of people
Gene and evidence
Three forms of APOE, one amino acid apart, and what two copies of ε4 do to timing, amyloid and blood vessels.
Drugs
Approved and investigational treatments, and what they mean for ε4/ε4.
Trials and studies
Drug trials and observational studies in ε4/ε4 carriers, and trials that report results by genotype.
Resources
Cohorts and repositories with ε4/ε4 data, and how to access them.
Key papers
The studies that define what we know, grouped by topic.
Newsletter
Research updates on APOE4 in your inbox.
Recently updated
What’s new
- Nov 2026 · Drugs: where lecanemab and donanemab are approved for ε4/ε4, and US costs.
- Oct 2026 · Trials and studies now include observational studies enrolling by APOE genotype.
- Oct 2026 · MGB Biobank added to Resources; sources now shown as ↗ links.
- Oct 2026 · New Start here page for people who have just learned they are ε4/ε4.
- Oct 2026 · Trial statuses checked against registries; donanemab ARIA rates by genotype added to Trials.
- Oct 2026 · New chart of APOE ε4 risk by ancestry on Gene and evidence.
- Oct 2026 · AD Workbench, All of Us and SEA-AD added to Resources.
- Oct 2026 · Glossary of genetics, biomarker and trial terms.
- Oct 2026 · Site launched.